Simulations

Two myosin clusters, one of them (right cluster) hanging on to the barbed (plus) end of an actin filament. The motor domains of the myosins on the other (left) cluster occasionally find the actin filament in an appropriate orientation to bind, through their brownian search. The motors do their thing, walking the left cluster along the actin filament. This is one basic tension-producing element in cells.
A broad ~20µm band of myosin clusters, with boundary conditions on the peripheral clusters. Each cluster can nucleate and hold onto actin filaments through the action of formins. In this “for demonstration purposes only” simulation, the interior clusters are also restricted to lateral motion. Actin filaments from each cluster reach out to neighboring clusters, and myosins work to walk all the clusters together.